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Salmon DNA Therapy—commonly known as PDRN (Polydeoxyribonucleotide) or PN (Polynucleotides)—is an advanced regenerative skin treatment designed to support hydration, promote skin repair, and enhance overall radiance. Originally studied for wound healing, polynucleotide-based skincare has gained popularity in aesthetic medicine worldwide due to its ability to help the skin look healthier, smoother, and more refreshed.
At Pines Aesthetics Center, L.L.C., proudly serving Broward and Miami-Dade County, we offer medical-grade Salmon DNA formulations as a cosmetic adjunct to support skin quality, hydration, and revitalization.
Salmon DNA” refers to purified polynucleotides extracted from salmon or trout DNA. These molecules are highly biocompatible and known for their ability to:
Support cellular regeneration
Enhance hydration and elasticity
Promote a healthier skin environment
Improve overall skin appearance
In aesthetics, Salmon DNA is used as a skin-quality booster, not a filler.
It does not create volume; instead, it helps the skin behave more youthfully by supporting repair and hydration.
Salmon DNA (PDRN/PN) is used cosmetically to support improvements in:
Skin Quality
Fine, crepey texture
Dull or tired skin
Loss of elasticity
Visible dehydration
Uneven tone
Skin Healing Support
Post-procedure recovery
Redness and sensitivity
Barrier support
Delicate Areas
Under-eye fine lines
Neck crepiness
Décolleté rejuvenation
Note: Results vary and tend to be subtle and cumulative.
When injected or applied after microneedling:
Polynucleotides bind water, improving hydration.
They interact with skin receptors that support natural healing.
Inflammation reduces, helping the skin look more balanced.
Over several weeks, the skin may appear smoother and more radiant.
Salmon DNA does not act like a traditional HA filler.
It is a skin booster, focused on quality and glow.
This treatment may be appropriate for individuals who want to:
Improve hydration and glow
Refresh delicate or aging skin
Support post-procedure healing
Enhance under-eye appearance
Try a regenerative skin-booster approach
Avoid volumizing fillers
Not recommended for pregnant or breastfeeding individuals.
During your session:
The skin is cleansed and numbed (if injected)
Salmon DNA is applied or injected superficially
Treatment time: 20–30 minutes
Minimal discomfort
It can be paired with microneedling, RF microneedling, PRP/PRF, or skin boosters for enhanced results.
What to Expect
Mild redness or swelling for 24–48 hours
Light sensitivity in delicate areas (under eyes)
No significant downtime
Improved hydration: 3–7 days
Enhanced glow: 1–3 weeks
Cumulative improvement with 3–4 sessions
Maintenance every 3–6 months is common.
Yes. PDRN/PN is highly purified and biocompatible; reactions are uncommon.
No—Salmon DNA boosts skin quality, not volume.
No. It is used cosmetically based on international research and is considered an emerging aesthetic option
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